Why Two Breast Cancer Drugs Don't Help Survival
Although Sutent and Avastin do shrink breast cancer tumors and slow the rate at which cancer develops, their effects have only a short-term benefit. The cancer eventually returns with a vengeance, growing and spreading to other organs.
Study author Max Wicha, M.D. wrote, "This study provides an explanation for the clinical trial results demonstrating that in women with breast cancer antiangiogenic agents such as Avastin delay the time to tumor recurrence but do not affect patient survival. If our results apply to the clinic, it suggests that in order to be effective, these agents will need to be combined with cancer stem cell inhibitors, an approach now being explored in the laboratory."
The research team conducted their study by administering Avastin and Sutent to lab mice with breast cancer. Both of these drugs halted the growth of blood vessels that typically feed a tumor. However, they also found these medications trigger the development of more cancer stem cells. Cancer stem cells help a tumor grow and spread and are highly resistant to drug therapy.
After the mice were treated with either drug, the researchers found that the number of cancer stem cells increased. They believe the cause of this phenomenon is due to a cellular response to low oxygen. The researchers were also able to determine the pathway that responded to low oxygen and activated these stem cells.
Avastin, which is FDA approved for several cancers, has had its approval for breast cancer therapy revoked. The Agency claims that the clinical trials had demonstrated that Avastin’s effects were not long-term; patients would soon relapse, with their cancer spreading at full force.
The authors believe that perhaps these drugs could be administered with a cancer stem cell inhibitor to boost their efficacy. They added that according to initial data from an ongoing study, this suggested approach appears to be effective.
2799 W Grand Blvd
Detroit, MI 48202
Call: (313) 556-8865
300 Longwood Ave
Boston, MA 02115
Call: (617) 355-7686
525 E 68th St # F-739
New York, New York 10065
Call: (212) 746-5145
600 N. Wolfe Street
Baltimore, Maryland 21287
2330 Eastchester Road
Bronx, NY 10469
Call: (718) 732-4000