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Obesity Drugs May Fight Cancer

Jeffrey Smith, Ph.D. of the Burnham Institute in California published his results of his study in a 2004 issue of Cancer Research in which he claims a commonly prescribed anti-obesity drug many inhibit cancer growth.

The metabolism of a tumor cell is different from its normal counterpart cell. Scientists have long suspected that metabolism is connected to tumor progression. Dr. Smith and co-workers compared normal prostate cells with prostate cancer cells and discovered that the prostate cancer cells are affected by an increased activity of fatty acid synthase. Fatty acid synthase is the enzyme that converts dietary carbohydrate to fat. The researchers then identified orlistat, a common anti-obesity drug marketed by Roche as XenicalTM, as an inhibitor of fatty acid synthase.


The initial research was done in vitro and then extended to mice studies. When they administered orlistat to mice bearing prostate tumors, the Smith laboratory discovered that the drug was able to inhibit tumor growth in mice. Further experiments confirmed that orlistat has no effect on normal prostate cells and no apparent side effects in the mice; it acts specifically as fatty acid synthase.

Additional screening of breast cancer and colon cancer cells revealed that fatty acid synthase activity is unregulated in these tumors as well. These findings, while preliminary,  open the door to designing new treatments for these cancers based on inhibiting the enzyme's activity with drugs that inhibits its activity.  

"This discovery with orlistat has given us a very nice wedge with which we can go in and perturb tumor cells and ask the question, 'What are the active targets, what are the other changes that take place when you inhibit fatty acid synthase?'", says Dr. Smith, "and that will give us really good insights into the mechanism, and we anticipate that's going to reveal a whole swath of additional drug targets along this pathway. This is a big advance in the sense that we have an approved drug--approved for one indication--that has another target and another potential disease indication, prostate cancer."

Dr. Smith is Associate Scientific Director for Technology at The Burnham Institute, where he is also an Associate Professor in the Institute's NCI-designated Cancer Center.

Co-authors contributing to this study include Drs. Steven J. Kridel and Fumiko Axelrod, postdoctoral fellows at The Burnham Institute, and Dr. Natasha Rozenkrantz of Activix Biosciences in La Jolla.

Chemotherapy Doctor Bronx

Dr. Fabio Volterra Dr. Fabio Volterra Eastchester Center for Cancer Care
2330 Eastchester Road
Bronx, NY 10469
Call (888) 860-7136

Chemotherapy is an option that Dr. Lucia Boselli may prescribe for cancer patients who see her in the Bronx. The treatment destroys cancer cells by stopping them from growing or multiplying. Healthy cells can also be harmed, but they usually repair themselves after chemotherapy. Dr. Boselli is a consulting physician at the Eastchester Center for Cancer Care.


Natural Cancer Cures Atlanta, Georgia

Dr. Slava Pashkevich, M.D. Dr. Slava Pashkevich, M.D. Immune Recovery Foundation, LLC
4646 N. Shallowford Rd
Atlanta, GA 30338
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The cancer journey is long and demanding for everyone involved. In recent years cancer rates in the United States has approached epidemic levels and conventional medicine is failed, in large part, to keep up. Many people looking for more choices to fight cancer have turned to those offering natural cancer cures. At the Immune Recovery Foundation, they hope to offer an alternative chemotherapy. This method of treatment called Insulin Potentiation Therapy (IPT) hopes to provide the same level of care while exposing healthy tissue to fewer toxins. IPT combined with immunotherapy and holistic care hopes to provide people in the Atlanta, Georgia area with another way to fight cancer.


LAP BAND Surgery Westchester, New York

 The Columbia University Center for Obesity Surgery at Lawrence Hospital The Columbia University Center for Obesity Surgery at Lawrence Hospital Lawrence Hospital Center | Center for Advanced Surgery
55 Palmer Avenue, First Floor
Bronxville, NY 10708
Call 888-468-9351

Your weight does have a bearing on your health, especially if you are obese. In cases of severe obesity, surgery like the Lap Band may be necessary. If you live in or around Westchester, New York, the Lawrence Hospital Center's Center for Advanced Surgery has a reputation for excellence due to its service, clinical quality, and advanced technology. A caring and experienced team will work with you every step of the way to give you the support you need to make your weight loss a success.


Weight Loss Surgery Yonkers

Dr. Miguel Silva Dr. Miguel Silva The Columbia University Center for Obesity Surgery at Lawrence Hospital
55 Palmer Avenue
Bronxville, NY 10708
Call 888-468-9351

If obesity is threatening your health, if you find your body unresponsive to diet and exercise alone, and you don't know where to turn, then Lawrence Hospital-Center for Advanced Surgery in Yonkers can help. This innovative facility offers the most advanced weight loss surgeries available, and has a group of caring professionals led by Dr. Daniel Davis who will work with you throughout your treatment, and support you as your reach your goals.


Anti Aging Henderson Nevada

Dr. Daniel Royal Dr. Daniel Royal New Hope Medical
9065 S Pecos Road, Suite 240
Henderson, Nevada 89074
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Over the last ten years, a much greater understanding of holistic health and its impact on Anti Aging treatments has revolutionized the practice at the New Hope Medical Center of Henderson, Nevada. Dr. Daniel Royal has years of experience of effectively building treatment plans that are best suited to the individual's physiological system.


Skin Cancer Doctor Manhattan, NY 10016

Dr. Tauseef Ahmed, M.D. Dr. Tauseef Ahmed, M.D. Westchester Oncology & Hematology
19 Bradhurst Avenue
Hawthorne, NY 10532
Call 888-370-4284

With so many doctors to choose from these days, it's hard to make a decision without at least some doubt. But if you're looking for the best skin cancer doctor around, go ahead and lay those doubts to rest; Dr. Tauseef Ahmed serves Manhattan and is the one specialist you'll want to have on your side when the going gets tough. He is an authority in the world of oncology and has the resume to show for it.



Tumor Biopsy Sarasota, Florida

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Biopsy Sarasota County, Florida



Pathology Testing Services Westchester County, New York

 Outpatient Services | Laboratory & Pathology Services Outpatient Services | Laboratory & Pathology Services Lawrence Hospital Center | Outpatient Services
55 Palmer Avenue
Bronxville, NY 10708
Call (888) 281-4612

Being unsure about disease or illness can be very difficult to live with. Finding effective treatment, or preventing it from getting worse is impossible without knowing what you're dealing with. How can you fight a condition that you know nothing about? If you or a loved one is looking for pathology testing services in the Westchester County, New York area, Lawrence Hospital Department of Outpatient Services can help. Serving the community for the past 90 years, the team of technologists, Pathologists and Phlebotomists perform over 600,000 tests annually. The team knows that results and healing is about much more than the numbers, so they work closely with patients and their families to make sure then understand every aspect.


Heart Surgery Manhattan, NYC

 Columbia University Medical Center Division of Cardiothoracic Surgery Columbia University Medical Center Division of Cardiothoracic Surgery Columbia University Medical Center Division of Cardiothoracic Surgery
Milstein Hospital Building, 7-435, 177 Fort Washington Avenue
Manhattan, NY 10032
Call 718-509-9178

The Cardiac Surgery Program at Columbia University Medical Center in Manhattan, NYC is ranked among the best in the world. They are known for their innovative research, and also for the creation of new, minimally invasive surgical techniques. They perform over 1,600 open heart surgeries annually.



Cancer Information Center Westchester

 Zalmen A. Arlin Cancer Institute Zalmen A. Arlin Cancer Institute The Zalmen A. Arlin Cancer Institute
19 Bradhurst Ave, Ste 2100
Hawthorne, NY 10532
Call (888) 850-9152

Westchester County's, Zalmen A. Arlin Cancer Institute at WCMC's Hawthorne / Valhalla campus is solely dedicated to delivering comprehensive cutting edge tertiary level diagnostic, therapeutic and supportative oncologic services.


gastric bypass surgery San Antonio, Texas

Dr. Jorge L. Rincon, MD FACS Dr. Jorge L. Rincon, MD FACS San Antonio Weight Loss Center
730 N. Main Ave. Suite #601
San Antonio, TX 78205
Call 888-705-2542

A cycle of diet after diet, losing weight just to gain it back again, is exhausting, frustrating and bad for your health. Living with obesity is harmful to health in the long run, so you should consider gastric bypass surgery at San Antonio Weight Loss Center in San Antonio, Texas. Dr. Jorge L. Rincon, MD can help you just as you're about to give up all hope of losing weight sufficiently. The surgeons there are willing, patient and ready to help you on the path to true health and wellness through gastric bypass surgery. When you want experience, then you should go to Dr. Rincon. He has been the primary surgeon on over 500 weight loss procedures and will create a customizable treatment program that has you in mind. There will also be a comprehensive post-op education for patients so that they are prepared for a new lifestyle, and move on from a life of obesity.


Lyme Disease Jacksonville, Florida

Dr. Bridget Freeman Dr. Bridget Freeman Atlantis Medical Center PA
1617 Thacker Ave
Jacksonville, Florida 32207
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No one expects to be afflicted with an agonizing disease when hiking in the woods or playing with your pet, but Lyme Disease can do just that. A debilitating illness, it can change the way you would normally live life. Dr. Bridget Freeman, M.D., and her team at Atlantis Medical Center in Jacksonville, Florida can help treat the disease without using machines and keeping a very personal relationship with patients.


Pain Management Boca Raton, FL

Dr. Brazelia Lazzari Dr. Brazelia Lazzari Brazelia Med Spa
Royal Palm Plaza
101-G Plaza Real So., Boca Raton, FL 33432
Call 888-229-3617

If you are in need of a pain management plan to ease you aches and pains and do not want to put yourself at risk of complications that often develop through the reliance on drug treatment and surgical procedures, the Brazelia Med Spa in Boca Raton, FL may have the answers for your needs. Dr. Brazelia Lazzari uses a holistic approach to care for pain management.



Integrative Medicine Fairfield, Connecticut

Dr. Associates in Family Chiropractic & Natural Health Care, P.C. Dr. Associates in Family Chiropractic & Natural Health Care, P.C. Associates in Family Chiropractic & Natural Health Care, P.C.
156 East Avenue
Norwalk, CT 06851
Call (203) 242-0165

Are you looking for a healthy and multidisciplinary way to increase your health? Do you want to help yourself under the care of professionals who offer a diverse approach to medicine? With integrative medicine at the Associates in Family Chiropractic & Natural Health Care, P.C. near Fairfield, Connecticut, you can optimize your health with help from Dr. Risa Sloves.


Free Obesity Surgery Seminar Manhattan, NYC

 Columbia University Medical Center for Metabolic and Weight Loss Surgery Columbia University Medical Center for Metabolic and Weight Loss Surgery Columbia University Medical Center | Center for Metabolic and Weight Loss Surgery
The Herbert Irving Pavilion,161 Fort Washington Avenue, 6th Floor, Room 620
New York City, NY 10032
Call 888-838-9148

You know how tough living with obesity can be. Every doctor is telling you the same thing; lose weight. Much easier said then done. If you're struggling to loose the weight needed for your health, its time to find an obesity surgeon that understands how tough battling obesity can be. Achieving a healthier and happier life takes a team effort. At the Center for Obesity Surgery at Columbia Medical Center the group of board-certified surgeons can help you feel comfortable and proud of your body again.


Herniated Disc Westchester, NY 10530

Dr. Bennie Chiles Dr. Bennie Chiles Westchester Spine and Brain Surgery, PLLC
280 N. Central Ave Suite 235
Hartsdale, NY 10530
Call (888) 281-4568

Suffering from a herniated disc? Consider spine surgery with Double Board Certified Dr. Bennie Chiles III. He is an attending neurosurgeon at a number of prominent hospitals in the New York area. Dr. Chiles offers treatment for a range of spinal disorders.



Back Pain Bronx, New York

Louis E. Bisogni, DC & Alan H. Siegel, DC Westchester Non-Surgical Spine and Sports Care
12 Old Mamaroneck Rd.
Wht Plns, NY 10605
Call (914) 202-0700

If you are among the millions of Americans that suffer from back pain and are seeking safe and effective back pain treatment without the use of drug therapies or surgical procedures, turn to Westchester Non-Surgical Spine and Sports Care serving the Bronx, New York. A team of caring doctors with the latest and most innovative treatments in the field of non-invasive care shown to ease a variety of lower back disorders while increasing each patient's range of mobility is waiting to help you.


Weight Loss Clinic Carson City, Nevada

Dr. Frank Shallenberger Dr. Frank Shallenberger Nevada Center for Alternative and Anti-Aging Medicine
1231 Country Club Drive
Carson City, NV 89703
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Losing weight is a great way to proactively improve your health, but many people who lose the weight regain it in a short amount of time, and it can become a frustrating cycle. Dr. Frank Shallenberger and the Weight Loss Clinic at the Nevada Center for Alternative and Anti-Aging Medicine in Carson City, Nevada can provide you with a program for healthy weight loss that will enable you to reach your weight loss goals and stay there.



Computed Tomography (Cat Scan)

Dr. Alfred Rosenbaum Dr. Alfred Rosenbaum The Eastchester Center for Cancer Care
2330 Eastchester Road
Bronx, NY 10469
Call (888) 860-7136

Is a CAT scan in your future? Get cancer detected early and nip it in the bud. A radiation oncologist like Dr. Alfred Rosenbaum, at Eastchester Center for Cancer Care in the Bronx, can make all the difference with his skill and experience. He is certified by the American Board of Radiology.


Oncologist

 Emil J. Freireich, M.D., D.Sc. Emil J. Freireich, M.D., D.Sc. The University of Texas M. D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, TX 77030
Call 713-792-2121

Dr. Freireich has served as a pillar in the development of a therapy for cancers, mainly leukemia. He began his career ad the National Cancer Institute in 1955 before moving to his present position as the M.D. Anderson Cancer Center in 1965. He was one of the pioneers in the development of the platelet replacement transition for the management of thrombocytopenia.