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Obesity Drugs May Fight Cancer

Jeffrey Smith, Ph.D. of the Burnham Institute in California published his results of his study in a 2004 issue of Cancer Research in which he claims a commonly prescribed anti-obesity drug many inhibit cancer growth.

The metabolism of a tumor cell is different from its normal counterpart cell. Scientists have long suspected that metabolism is connected to tumor progression. Dr. Smith and co-workers compared normal prostate cells with prostate cancer cells and discovered that the prostate cancer cells are affected by an increased activity of fatty acid synthase. Fatty acid synthase is the enzyme that converts dietary carbohydrate to fat. The researchers then identified orlistat, a common anti-obesity drug marketed by Roche as XenicalTM, as an inhibitor of fatty acid synthase.


The initial research was done in vitro and then extended to mice studies. When they administered orlistat to mice bearing prostate tumors, the Smith laboratory discovered that the drug was able to inhibit tumor growth in mice. Further experiments confirmed that orlistat has no effect on normal prostate cells and no apparent side effects in the mice; it acts specifically as fatty acid synthase.

Additional screening of breast cancer and colon cancer cells revealed that fatty acid synthase activity is unregulated in these tumors as well. These findings, while preliminary,  open the door to designing new treatments for these cancers based on inhibiting the enzyme's activity with drugs that inhibits its activity.  

"This discovery with orlistat has given us a very nice wedge with which we can go in and perturb tumor cells and ask the question, 'What are the active targets, what are the other changes that take place when you inhibit fatty acid synthase?'", says Dr. Smith, "and that will give us really good insights into the mechanism, and we anticipate that's going to reveal a whole swath of additional drug targets along this pathway. This is a big advance in the sense that we have an approved drug--approved for one indication--that has another target and another potential disease indication, prostate cancer."

Dr. Smith is Associate Scientific Director for Technology at The Burnham Institute, where he is also an Associate Professor in the Institute's NCI-designated Cancer Center.

Co-authors contributing to this study include Drs. Steven J. Kridel and Fumiko Axelrod, postdoctoral fellows at The Burnham Institute, and Dr. Natasha Rozenkrantz of Activix Biosciences in La Jolla.

Heavy Metal Detox Jacksonville, Florida

Dr. Bridget Freeman Dr. Bridget Freeman Atlantis Medical Center PA
1617 Thacker Ave
Jacksonville, Florida 32207
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Heavy metals are everywhere in our daily lives. It is in our food, our drinking water, and in nature itself. Dr. Bridget Freeman, M.D., and the professionals at Atlantis Medical Center in Jacksonville, Florida, can help you detox your body from harmful heavy metals and get your system back on the right track.


Integrative Medicine Fairfield, Connecticut

Dr. Adrian Marcus Dr. Adrian Marcus Back & Neck Pain Center of Greenwich, P.C.
100 Melrose Ave # 101
Greenwich, CT 06830
Call (888) 847-1821

Are you looking for a healthy and multidisciplinary way to increase your health? Do you want to help yourself under the care of professionals who offer a diverse approach to medicine? With integrative medicine at the Back & Neck Pain Center of Greenwich, P.C. in Fairfield, Connecticut, you can optimize your health with help from Dr. Adrian Marcus.


Breast Cancer Surgery

Dr. Nella I. Shapiro Dr. Nella I. Shapiro Eastchester Center for Cancer Care
2330 Eastchester Road
Bronx, NY 10469
Call (888) 860-7136

Are you suffering from breast cancer? Get treated by a breast cancer surgeon who will stop at nothing when it comes to your welfare. At Eastchester Center for Cancer Care in the Bronx Dr. Nella Irene Shapiro can offer you state-of-the-art breast cancer treatment. She is certified by the American Board of Surgery.


Oncology/Oncologist Westchester NY 10532

Dr. Tauseef Ahmed, M.D. Dr. Tauseef Ahmed, M.D. Westchester Oncology & Hematology
19 Bradhurst Avenue
Hawthorne, NY 10532
Call (888) 850-9152

Dr. Ahmed is a Professor of Medicine, Chief of Oncology / Hematology and Neoplastic Diseases at the New York Medical College. He is also the Medical Director of the Zalmen A. Arlin Cancer Institute at Westchester Medical Center.



Oncologist

 Emil J. Freireich, M.D., D.Sc. Emil J. Freireich, M.D., D.Sc. The University of Texas M. D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, TX 77030
Call 713-792-2121

Dr. Freireich has served as a pillar in the development of a therapy for cancers, mainly leukemia. He began his career ad the National Cancer Institute in 1955 before moving to his present position as the M.D. Anderson Cancer Center in 1965. He was one of the pioneers in the development of the platelet replacement transition for the management of thrombocytopenia.


Dr. Brazelia Lazzari

Dr. Brazelia Lazzari Dr. Brazelia Lazzari Brazelia Med Spa
Royal Palm Plaza
101-G Plaza Real So., Boca Raton, FL 33432
Call 888-229-3617

Dependency and addiction to prescription drugs is a growing problem in America, and is leading many in the general public to seek out alternative and naturopathic forms of health care and medicine. Dr. Brazelia Lazzari, with the Absolute Balance of Life Health and Wellness Center in Boca Raton, Florida, specializes in traditional Chinese Medicine and focuses on a holistic approach to overall well-being.



Neurosurgeon Westchester, NY 10530

Dr. Bennie Chiles Dr. Bennie Chiles Westchester Spine and Brain Surgery, PLLC
280 N. Central Ave Suite 235
Hartsdale, NY 10530
Call (888) 281-4568

Our practice is affiliated with all major hospitals throughout Westchester County. We offer comprehensive surgical spine care for a wide variety of simple and complex conditions, involving degenerative disease, trauma, tumor, infection, and congenital disorders.



Weight Loss Surgery Center Westchester, New York

 The Columbia University Center for Obesity Surgery at Lawrence Hospital The Columbia University Center for Obesity Surgery at Lawrence Hospital Lawrence Hospital Center | Center for Advanced Surgery
55 Palmer Avenue, First Floor
Bronxville, NY 10708
Call 888-468-9351

One of the largest health risks in the United States today is obesity and the disorders that occur as a result of obesity. Without proper medical support, the effects of obesity can lead to potentially life threatening illnesses and conditions. At the Center for Advanced Surgery at Lawrence Hospital Center in Westchester, NY, experienced and certified doctors understand that, in some cases, it may take more than just diet and exercise to help patients reach a healthy weight. For this reason they have developed safer techniques in weight loss surgery to provide support to those who seek the benefits of a surgical procedure with minimal risks.


Cervical Cancer Specialist Osceola, Florida

 Osceola Cancer Center Osceola Cancer Center Osceola Cancer Center
737 West Oak Street
Kissimmee, Florida 34741
Call (888) 287-5593

Cervical Cancer is an illness that targets women of all ages. If you have also been diagnosed with this disease, you should get the treatment and support you need to keep it under control. In fact, receiving quality care can help significantly reduce the severity of your condition, so that you can go on living a normal and fulfilling life, despite your illness. Also, with the proper guidance, you can also gain a healthy mindset, which is strongly linked with improving overall health. The place to receive optimal service that encompasses your every need during this difficult time is Osceola Cancer Center in Osceola, Florida. There, you will be met with a Cervical Cancer Specialist who will give you the tools and input you need to increase your chances of living a healthier existence and work towards fighting against your condition as well as you can.


Treatments for Cancer Philadelphia, Pennsylvania

Cancer Treatment Centers of America Cancer Treatment Centers of America
1331 East Wyoming Avenue
Philadelphia, Pennsylvania 19124
Call (888) 353-8036

Finding the proper place and  treatments for cancer can be difficult. As you seek treatments for cancer during this difficult time, you want to be sure that you are receiving the best care possible for you and your loved ones. At Cancer Treatment Centers of America, we use a comprehensive and integrative approach to fighting cancer. By combining conventional and modern techniques, our professional staff is able to treat all of you, not just your disease. Our cancer treatment center in Philadelphia, Pennsylvania is dedicated to providing each client with the care and support they need to fight back against cancer.



Heart Surgery Manhattan, NYC

 Columbia University Medical Center Division of Cardiothoracic Surgery Columbia University Medical Center Division of Cardiothoracic Surgery Columbia University Medical Center Division of Cardiothoracic Surgery
Milstein Hospital Building, 7-435, 177 Fort Washington Avenue
Manhattan, NY 10032
Call 718-690-7415

The Cardiac Surgery Program at Columbia University Medical Center in Manhattan, NYC is ranked among the best in the world. They are known for their innovative research, and also for the creation of new, minimally invasive surgical techniques. They perform over 1,600 open heart surgeries annually.



Lung Cancer Treatment Florida

 Osceola Cancer Center Osceola Cancer Center Osceola Cancer Center
737 West Oak Street
Kissimmee, Florida 34741
Call (888) 287-5593

Lung Cancer affects the lives of thousands of Americans and their families and it is a constant struggle. This is why the team of professional doctors at Osceola Cancer Center has dedicated their lives to caring for those who suffer from this terrible affliction. Based in Florida, they offer their patients a welcoming environment that focuses on extraordinary personal care and uses only the most state of the art treatments to offer you superior Lung Cancer Treatment.


Weight Loss Clinic Reno, Nevada

Dr. Frank Shallenberger Dr. Frank Shallenberger Nevada Center for Alternative and Anti-Aging Medicine
1231 Country Club Drive
Carson City, NV 89703
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You've tried weight loss medication, diets, and exercise plans but you can't seem to lose the weight. When you manage to lose a few pounds, it always comes back. Also, diets have left you tired and weak. The Nevada Center of Alternative and Anti-Aging Medicine in the Reno, Nevada area offers a weight loss clinic that targets many of the causes of weight gain.



Obesity Surgery Larchmont

 The Columbia University Center for Obesity Surgery at Lawrence Hospital The Columbia University Center for Obesity Surgery at Lawrence Hospital Lawrence Hospital Center | Center for Advanced Surgery
55 Palmer Avenue, First Floor
Bronxville, NY 10708
Call 888-468-9351

Obesity is quickly becoming a large threat to the American population. According to the Center for Disease Control and Prevention, in 2003-2004, obesity has risen to 32.9% in young adults aged 20-74. In order to help battle this problem, the Lawrence Hospital Center for Advanced Surgery offers various Obesity Surgeries to help patients in Larchmont finally kick the extra pounds to the curb and help them live a normal and healthy life.


Chronic Pain Boulder City, Nevada

Dr. Daniel Royal Dr. Daniel Royal New Hope Medical
9065 S Pecos Road, Suite 240
Henderson, Nevada 89074
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Living with chronic pain can affect your life in ways you didn't even imagine. Chronic pain can influence your health, your happiness, your drive to get out of bed in the morning. Chronic pain has numerous potential causes and requires an experienced diagnosis to determine a proper treatment. Dr. Daniel Royal, DO, JD, HMD provides expert care at the New Hope Medical Center in Boulder City, Nevada.


LAP BAND Surgery Baytown, Texas

 Lap Band Center of Houston Lap Band Center of Houston Lap Band Center of Houston
2525 W Bellfort St. #120
Houston, TX 77054
Call 281-207-8640

Do you find it difficult to lose the weight needed for your health? Every day people like you struggle though diet after diet trying to rid themselves of obesity. But in today's world of overly-processed and unhealthy food it can seem impossible. If you feel like you need assistance and guidance to lose the unhealthy pounds, [Your Practice Name Here] is there to help.



Magnetic Resonance Imaging (MRI) Bronx

Dr. Lucia Boselli Dr. Lucia Boselli Eastchester Center for Cancer Care
2330 Eastchester Road
Bronx, NY 10469
Call (888) 860-7136

Suspect you have a malignancy? Don’t despair. Magnetic resonance imaging (MRI) can detect cancer and help you nip it in the bud. Dr. Lucia Boselli at Eastchester Center for Cancer Care is an experienced medical oncologist. Eastchester offers state-of-the-art techniques in cancer detection and treatment.


Lap Band Surgery Bronxville, Eastchester, Westchester County, NY

Dr. Daniel G. Davis Dr. Daniel G. Davis The Columbia University Center for Obesity Surgery at Lawrence Hospital
55 Palmer Avenue
Bronxville, NY 10708
Call 888-468-9351

Do you suffer from obesity? Are exercise and diet just not doing the ob when it comes to weight loss? You could be genetically pre-disposed to obesity, which makes it impossible to lose weight using conventional methods (exercise and diet). Many people do not know there is another method to losing weight at a consistent healthy pace, weight loss surgery. Dr. Daniel G. Davis, DO, of Lawrence Hospital Center in Bronxville, Eastchester, Westchester County, NY, is capable of performing Lap Band surgery.


Medical Laboratory Services Westchester County, New York

 Outpatient Services | Laboratory & Pathology Services Outpatient Services | Laboratory & Pathology Services Lawrence Hospital Center | Outpatient Services
55 Palmer Avenue
Bronxville, NY 10708
Call (888) 281-4612

Are you of a loved unsure about a possible genetic disease or disorder? In order to make the right choices for your health and well-being, you need to understand the essentials of your condition. At the Lawrence Hospital Department of Outpatient Services they carry out over 600,000 tests annually for the Westchester County, New York community. They understand that results are more than the numbers so Dr. Jose Maccera, MD chooses works closely with patients and their families to make sure they understand each detail. If you're searching for medical laboratory services contact Lawrence Hospital today.


Bronx Weight Loss Surgery

 Columbia University Medical Center for Metabolic and Weight Loss Surgery Columbia University Medical Center for Metabolic and Weight Loss Surgery Columbia University Medical Center | Center for Metabolic and Weight Loss Surgery
The Herbert Irving Pavilion,161 Fort Washington Avenue, 6th Floor, Room 620
New York City, NY 10032
Call 888-857-1803

The decision to do something about your Obesity is a big step to take. Weight Loss Surgery is dangerous, but by calling the Center for Obesity at Columbia University in NYC, you will be making a great choice about who will administer your weight loss surgery.