New Imaging Platform Allows for Targeted Cancer Research

Posted by Admin on February 28, 2012

Cancer is most dangerous and deadly when its cells become aggressive and spread throughout the body. Unfortunately, scientists still have very little information about how to stop the aggressive development of cancer cells before metastasizing begins. Researchers at the Lawson Research Institute have created a new imaging platform that may give scientists a much more accurate and real-time picture of how cancer develops and how it can be stopped.

Cells rely on certain proteins, such as E-cadherin, to regulate and maintain normal tissue structure. Scientists have found that when cancer cells become more aggressive, they often lose E-cadherin, allowing them to grow and spread completely unregulated. When the cells are forced to express E-cadherin, research suggests that their aggressive growth is stopped. However, scientists have previously been unable to study the full impact of the protein on cell regulation.

In a study published in the journal PLoS ONE, researchers created and used a new imaging platform to study the real-time effects of E-cadherin on a chick embryo implanted with human cancer cells. E-cadherin was injected directly into the cancerous tumor, and the researchers were able to monitor the effect of the protein on each individual cancer cell in the tumor in real time for a 48-hour period.

The researchers hope that their new technology will allow scientists to more closely study the effects of E-cadherin and other proteins on the growth and development of aggressive cancer cells. While several proteins have been identified through genomic research that may suppress tumor growth, they have not yet been validated through clinical trials on mice because scientists have not been able to determine the effects of the protein on each individual cancer cell. The authors of the study hope that their new technology will provide compelling photographic evidence of the effectiveness of certain proteins in tumor suppression and offer more insight into the mechanisms at work.


Disclaimer

Subscribe to our newsletter

Enter your email address to subscribe and receive notifications of new stories on Empowereddoctor.com

Featured Specialities:

Featured Doctors:

The Farber Center

Prostate Cancer Treatment NY

21 West Broadway
New York, NY 10007

Call: 888-460-0581

Optimal Wellness

Dr. Paul Dreschnack Dr. Paul Dreschnack
Reconstruction After Mohs Surgery NY

14 E.69th Street
New York, NY 10021

Call: 888-560-4045

The Eastchester Center for Cancer Care

Dr. Lucia Boselli
Brachytherapy Bronx NY 10469

2330 Eastchester Road
Bronx, NY 10469

Call: (888) 860-7136

Cancer Treatment Centers of America in Tulsa, Oklahoma

 Cancer Hospital in OK
Tulsa, Oklahoma Cancer Treatment Center

10109 E. 79th Street (81st Street & Highway 169)
Tulsa, OK 74133

Call: 800-655-1253