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Metal-Particle Inflammation Causes Joint-Implant Failure

The very joint implants that bring pain relief and restore freedom of motion to patients’ extremities can be their own undoing, setting off a metal-induced immunological defense mechanism that causes the implants to loosen and fail, according to a recent study.
   
The study, funded by the National Institutes of Health and to be published in the Journal of Orthopaedic Research, was conducted by researchers at Rush University Medical Center. It won an award for scientific merit from the Orthopaedic Research Society.


Up to 10 percent of total joint replacements – of which there are 600,000 a year in the United States – loosen and fail, requiring a second surgery to correct them. This failure is often caused by inflammation from particles of metallic debris that break loose as the metal components of the joint implant wear against each another.

“As soon as joint replacement devices are implanted, they begin to corrode and wear away, releasing particles and ions that ultimately signal danger to the body’s immune system,” said Nadim Hallab, associate professor at Rush University Medical Center and the study author.
   
Inflammation in the body can develop along two pathways – one that starts from bodies that cause infection, such as viruses and bacteria, and another triggered by non-infectious factors, such as ultraviolet light and oxidative stress. This study is the first to show that metal dust and ions from implants can begin this second inflammation cascade.
   
Describing this cascade, Hallab said that specialized immune-system “cleanup” cells, known as macrophages, first attack the metal dust. They “engulf it in sacs called lysosomes and try to get rid of the debris by digesting it with enzymes.” But the particles damage the lysosomes, Hallab said, “and the cells start screaming ‘danger.’”
   
Then large complexes of proteins, called inflammasomes, detect these chemical danger signals. The inflammasomes gather, setting off the cascade of chemical events causing inflammation.
   
Now that light has been shed on this pathway, Hallab and his colleagues said, the door may be open to developing new therapies to head off early failure of joint implants.

Achilles Tendon Las Vegas, Nevada (NV)

 R. Jeffrey Grondel, M.D. R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson, NV 89074
Call 702-932-9000

A weakening or rupture of the Achilles tendon causes a significant decrease in mobility and serious pain. Whether a result of sports injuries or a consequence of long-term wear and tear, it requires immediate attention and a skilled hand to repair it. Dr. R. Jeffrey Grondel of the Orthopaedic Institute of Henderson, NV near Las Vegas has been using his extensive experience to surgically repair ligaments, tendons and joints for years, and he wants to be the one to help you.


Orthopaedics Surgeon Westchester, NY

Dr. Daniel Zelazny Dr. Daniel Zelazny University Orthopedics
19 Bradhurst Avenue, Ste. 1300N
Hawthorne, NY 10532
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Injured your hand or foot at work or on the sports field? Consult with an orthopedic surgeon and get the treatment you need as soon as possible. Board certified Dr. Daniel Zelazny in Westchester, NY specializes in sports medicine and orthopedic trauma. He is an attending Orthopedic Surgeon at Westchester Medical Center, a cutting-edge medical research facility in the Hudson Valley region.



Shoulder Injury Paramus, Bergen County, NJ

Dr. Roger Pollock Dr. Roger Pollock Dr. Roger Pollock, M.D.
suite 202 One West Ridgewood Avenue
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Call (888) 631-1911

If a shoulder injury has limited your ability to work and play, you need to do seek help. In Paramus, New Jersey, Dr. Roger Pollock is a shoulder specialist who is well versed in all aspects of perhaps the most important joint in the body. Supported by caring individuals whose goal is to see you moving freely again, Dr. Pollock is best equipped to take care of you.


Sports injuries Henderson, Nevada (NV)

 R. Jeffrey Grondel, M.D. R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson, NV 89074
Call 702-932-9000

Athletes need treatment from a doctor who understands the specific demands placed on their bodies by their sport. Dr. R. Jeffrey Grondel, MD has devoted his education and training to the injuries sustained by athletes. If you have experienced a sports injury and feel that your medical care has been less competent than you would like, contact the Orthopaedic Institute of Henderson, Nevada. Dr. Grondel is one of the many qualified doctors at the Institute who can address the specific needs of athletes.


Achilles Tendon Rupture Henderson, Nevada (NV)

 R. Jeffrey Grondel, M.D. R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson, NV 89074
Call 702-932-9000

For severe trauma injuries like a ruptured Achilles tendon, the for surgery is immediate and urgent. The pain is awful, and the immobility is devastating. Based in Henderson, NV, Dr. R. Jeffrey Grondel, MD is experienced in the diagnosis and treatment of ruptured Achilles tendons.


Ligament Surgery Yonkers, New York

 Lawrence Hospital Center | Orthopedics & Sports Medicine Lawrence Hospital Center | Orthopedics & Sports Medicine Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville, NY 10708
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Finding a surgeon for ligament surgery can be a difficult task. First, you might think about what you need in a surgeon: skill, experience, compassion, dedication and affordability. The surgeons of the Orthopedic and Sports Medicine department of the Lawrence Hospital Center in Yonkers, New York encompass all of these qualities. If you need ligament surgery, the Lawrence Hospital Center is where you go.


Ankle Pain Relief Treatments Bronxville, Westchester County, New York

 Lawrence Hospital Center | Orthopedics & Sports Medicine Lawrence Hospital Center | Orthopedics & Sports Medicine Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville, NY 10708
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Do you feel pain in your ankle? Unsure of where to find relief for your pain? Ankle pain can put strain on the whole body. Often times an ankle injury can render a person immobile for long periods of time. Many people try to linger on with the pain, which may cause further injury to the ankle. Get the help you deserve from the Lawrence Hospital Center for Orthopedics and Sports Medicine in Bronxville, Westchester County, New York.


Shoulder Doctor Paramus, Bergen County NJ

Dr. Roger Pollock Dr. Roger Pollock Dr. Roger Pollock, M.D.
suite 202 One West Ridgewood Avenue
Paramus, New jersey 07652
Call (888) 631-1911

If you have sustained a shoulder injury and are seeking care from an experienced Shoulder Doctor in Bergen County NJ, turn to Roger G. Pollock, M.D. Dr. Pollock is a talented accredited professional, who specializes in advanced orthopaedic techniques of the shoulder.


Orthopedics San Diego, CA

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It is important to address musculoskeletal issues before the cause serious problems. This is especially important for children. Our Orthopedics center has been providing surgery and treatments to those suffering from orthopedic issues. We have skilled podiatrists who can access your situation and give you the right treatment. If you are living in San Diego, CA and have orthopedic issues, contact us.


Orthopedics San Francisco, CA

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For musculoskeletal issues originating from bad posture or foot conditions, visiting an Orthopedic doctor can prevent many long term physical issues. This fact is especially important for young people. Our center located in San Francisco, CA has been providing top notch orthopedic surgery and treatment to those who are in need. If you have any concerns or would like to see a doctor, contact our orthopedics center today.


Orthopedic Hip Surgery Westchester, NY

Dr. David Asprinio Dr. David Asprinio Westchester Medical Center
19 Bradhurst Avenue, Ste 1300N
Hawthorne, NY 10532
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Dr. David E. Asprinio is Director of Orthopedics at Westchester Medical Center, specializing in orthopaedic hip surgery and orthopaedic trauma. He is also Chairman and Program Director of New York Medical College - Department of Orthpaedic Surgery.


Orthopedic Surgeons New Rochelle, New York

 Lawrence Hospital Center | Orthopedics & Sports Medicine Lawrence Hospital Center | Orthopedics & Sports Medicine Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville, NY 10708
Call (888) 729-2857

Your knee has been aching a lot lately, and you're starting to worry that it might be a serious problem. Usually when a joint has been severely injured, it means surgery, and you want the best there is in orthopedic surgeons so that you can continue with life as if your injury had never happened. That's where the orthopedic surgeons of Lawrence Hospital Center near New Rochelle, New York come in. Having assembled a team of talented surgeons and rehabilitation experts for after care, you can rest easy knowing you are in talented and experienced hands.


Orthopedics Phoenix, AZ

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Are you in need of an orthopedic treatment center? It is important to address all posture issues as soon as possible in order to prevent future posture and structure issues. Phoenix, AZ is home to many different orthopedic doctors who can provide the service necessary to diagnose and provide treatment to any foot or ankle conditions. If you are in need of orthopedic doctor contact us today.


Reconstructive Orthopedic Back Surgery Bronxville, Westchester County, New York

 Lawrence Hospital Center | Orthopedics & Sports Medicine Lawrence Hospital Center | Orthopedics & Sports Medicine Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville, NY 10708
Call (888) 729-2857

Do you have chronic back pain? Have you recently fallen victim to a back injury? You may not be aware that you are need of reconstructive orthopedic back surgery. Over a million people a year have some form of reconstructive surgery. The surgery brings function back to the injured area of the patient. A decade ago this surgery was thought to be impossible, but the staff at Lawrence Hospital Center for Orthopedics and Sports Medicine in Bronxville, Westchester County, New York, is capable of such a surgery.


Woman (Gender) Knee Replacement

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55 Palmer Avenue, First Floor
Bronxville, NY 10708
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Hip replacement, knee surgery, shoulder surgery, and other orthopedic procedures are performed expertly at Lawrence Hospital Center Orthopedics & Sports Medicine near White Plains, NY.


Labral Repair Westchester, New York

Dr. Howard Luks Dr. Howard Luks University Orthopaedics
19 Bradhurst Ave. Ste 1300N
Hawthorne, NY 10532
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Are you looking for an experienced surgeon to perform your Labral repair operation in Westchester, New York? Dr. Howard J. Luks, MD and the rest of the team at University Orthopaedics, PC possesses the skill and dedication to provide you with quality medical care. Through their special commitment to patient education, the surgeons make the entire treatment process comfortable.



Partial Knee Replacement Henderson, Nevada (NV)

 R. Jeffrey Grondel, M.D. R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson, NV 89074
Call 702-932-9000

Severe arthritis of the knees leads to crippling pain and limited mobility. In some cases, partial knee replacement is necessary to regain control. For a long term solution to knee pain and osteoarthritis in Henderson, NV, Dr. R. Jeffrey Grondel is an orthopedic surgeon of exceptional skill.


Ceramic Knee Repalcement Westchester, NY

Dr. Howard Luks Dr. Howard Luks University Orthopaedics
19 Bradhurst Ave. Ste 1300N
Hawthorne, NY 10532
Call (888) 834-8517

Severe knee pain often limits the mobility of those it affects. You can't walk down the hall without wincing from the shooting, burning pain that smolders in the body's most complicated and, perhaps, important joint, and finding a solution to that pain becomes a critical necessity. Knee surgery is often needed for the worst cases of joint degeneration whether from osteoarthritis or injury, and a ceramic knee replacement is one of the newest and most functional replacements available. Dr. Howard Luks, M.D. helps restore the motion to people's lives each day at University Orthopaedics, P.C. in Westchester, New York with the finest techniques orthopedic medicine has to offer.



Sports Injury Las Vegas, Nevada

 R. Jeffrey Grondel, M.D. R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson, NV 89074
Call 702-932-9000

If your sidelined by a sports injury and are seeking an orthopedic doctor to get you back in the game, turn to Dr. R. Jeffrey Grondel. Dr. Grondel has extensive experience a in healing sports injuries. Located near Las Vegas, Nevada, the Orthopedic Institute of Henderson offers treatment for injuries of the knee, shoulder, elbow, and ankle.


Shoulder Surgery Las Vegas, Nevada

 R. Jeffrey Grondel, M.D. R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson, NV 89074
Call 702-932-9000

Long term, severe shoulder pain can really wear on you, but orthopedic surgery offers minimally invasive arthroscopic solutions for the repair of an injured shoulder, such as a rotator cuff tear. In Las Vegas, Nevada, Dr. R. Jeffrey Grondel has years of experience as an orthopedic surgeon focusing on sports medicine and has helped many patients return to an active lifestyle.