Insight Into Faster Healing of Seniors' Broken Bones
As people age, bone healing becomes slower and poorer. But a new drug may provide hope of restoring to seniors the rapid bone healing of youth, according to a recent study. The research, which is presented in the Journal of Bone and Mineral Research, offers hope to the roughly 560,000 Americans a year who suffer bone fractures that heal slowly or incompletely, leaving many in wheelchairs, unable to walk or live on their own. Even though the study is just on mice, it’s relevant to humans because of the similarity between a key human and mouse bone-building gene, and because the study mice, specially engineered by the National Institute on Aging, led to several important insights into aging that have been confirmed in humans.
The key bone-building gene is called the COX-2 gene, shorthand for cyclooxygenase-2, an enzyme that plays a vital role in cartilage and bone repair. COX-2 declines dramatically with age. “The skeleton loses the ability to repair itself as we age,” said Regis J. O’Keefe, chairman of the Department of Orthopaedics at the University of Rochester Medical Center and corresponding author of the article. “Our results position the COX-2 pathway as one of several under exploration with the common goal of accelerating healing in aging humans, and with the potential to come together in future combination therapies.” In the O’Keefe study, the bone-healing rates of two groups of mice – one young (seven-nine weeks of age) and one old (52-56 weeks of age) – were compared using imaging and gene-expression techniques. The expression of the COX-2 gene was far less in older mice than in young, and corresponded exactly with the onset of the key healing period. Most important, the researchers were able to reverse the loss of bone-healing ability in aging mice by using an experimental Pfizer drug that boosts the effect of COX-2. The drug fills a missing link that develops in the COX-2 cell-stimulation pathway in aged mice. As COX-2 levels diminish with age, the chain reaction that’s required to stimulate bone marrow stem cells, cartilage cells and bone-producing cells (osteoblasts) weakens to a trickle.
The experimental drug, CP-734432, apparently mimicked one element in the COX-2 pathway, boosting fracture repair in the older mice with more efficient formation of mature bone. The drug was also recently used to prevent osteoporosis in early animal studies.
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Lawrence Hospital Center | Orthopedics & Sports Medicine
Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville,
NY
10708
Call (888) 729-2857
It takes a lot of biology and locomotion to keep our bodies active each day. Our bones, muscles, joints and ligaments work together to give us mobility and flexibility. If you've sustained an injury or tear to a ligament, you know how painful it can be. Movement in that area can become very difficult. At the Lawrence Hospital Center for Orthopedic and Sports Medicine they offer ligament surgery for those who suffer from consistent pain from injury in the New Rochelle, New York area.
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Dr. Empowered Doctor
EMPOWERED DOCTOR Medical Marketing
Medical Marketing Service
for Medical Professionals,
Seattle
WA
Call 1-888-697-2630
For musculoskeletal issues it is important to address them as early as possible before they cause any other physical complications. Our orthopedic doctors are ready to treat your issues with treatment conducted in a professional environment. If you are interested in orthotics or need foot surgery, contact our Seattle, WA center today.
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Lawrence Hospital Center | Orthopedics & Sports Medicine
Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville,
NY
10708
Call (888) 729-2857
Hip replacement, knee surgery, shoulder surgery, and other orthopedic procedures are performed expertly at Lawrence Hospital Center Orthopedics & Sports Medicine near White Plains, NY.
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R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson,
NV
89074
Call 702-932-9000
Having a knee injury can really make your everyday life a lot more diffcult, affecting your performance on many levels. But, with the right care and attention from a well-trained and knowledgeable medical professional, you can finally be rid of your pain and resume an active lifestyle. In Las Vegas, Nevada, Dr. R. Jeffrey Grondel, M.D can provide you with cartilage repair to correct your damaged knee, improving your level of mobility and quality of performance regarding everyday activities.
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Lawrence Hospital Center | Orthopedics & Sports Medicine
Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville,
NY
10708
Call (888) 729-2857
Suffering from hand problems can change you in ways that you never thought possible. It can affect everything from how you get dressed in the morning and how you eat, to even how you perform at work. When you have reached a crisis point, the Lawrence Hospital Center for Orthopedics & Sports Medicine in Yonkers, New York are the people you need to contact to get on with your life.
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R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson,
NV
89074
Call 702-932-9000
The rotator cuff is an integral part of your shoulder. The muscles and tendons that stabilize your shoulder and keep it in place make up the rotator cuff. If you are living in or around Las Vegas, Nevada and are suffering from shoulder problems, visit Dr. R. Jeffrey Grondel, MD today.
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Dr. Howard Luks
University Orthopaedics
19 Bradhurst Avenue, Ste 1300N
Hawthorne,
NY
10532
Call (888) 834-8517
Are you suffering from Tennis Elbow? Has the pain continued for far too long? If so, Dr. Howard J. Luks, MD in Westchester can help you. At University Orthopaedics, PC, he specializes mainly on the treatment of Orthopaedic disorders of the Shoulder, Elbow, Knee and Ankle, and Tennis Elbow is a pain that spreads from the elbow, down to the forearm and then to the fingers.
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Lawrence Hospital Center | Orthopedics & Sports Medicine
Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville,
NY
10708
Call (888) 729-2857
Your knee has been aching a lot lately, and you're starting to worry that it might be a serious problem. Usually when a joint has been severely injured, it means surgery, and you want the best there is in orthopedic surgeons so that you can continue with life as if your injury had never happened. That's where the orthopedic surgeons of Lawrence Hospital Center near New Rochelle, New York come in. Having assembled a team of talented surgeons and rehabilitation experts for after care, you can rest easy knowing you are in talented and experienced hands.
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R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson,
NV
89074
Call 702-932-9000
Have you suffered from a serious traumatic impact to your knee that requires surgery? Let orthopedic surgeon Dr. R. Jeffrey Grondel, MD of Boulder City, Nevada examine and treat your injury. Whether its sports related or from daily wear and tear, Dr. Grondel's education, preparation and practice has seen a variety of joint replacement cases to give your injury the proper attention.
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R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson,
NV
89074
Call 702-932-9000
For severe trauma injuries like a ruptured Achilles tendon, the for surgery is immediate and urgent. The pain is awful, and the immobility is devastating. Based in Henderson, NV, Dr. R. Jeffrey Grondel, MD is experienced in the diagnosis and treatment of ruptured Achilles tendons.
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Dr. David Asprinio
Westchester Medical Center
19 Bradhurst Avenue, Ste 1300N
Hawthorne,
NY
10532
Call (888) 834-8517
Dr. David E. Asprinio is Director of Orthopedics at Westchester Medical Center, specializing in orthopaedic hip surgery and orthopaedic trauma. He is also Chairman and Program Director of New York Medical College - Department of Orthpaedic Surgery.
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R. Jeffrey Grondel, M.D.
100 North Green Valley Parkway Suite 310
Henderson,
NV
89074
Call 702-932-9000
Feeling, touching, grabbing, so much of the way we interact with the world is through our hands, and we tend to take it for granted until something goes wrong. If you need to have hand surgery, turn to Dr. R. Jeffrey Grondel, MD, who has years of professional experience to accompany the cutting edge technology. Dr. Grondel operates out of the respected Orthopaedic Institute of Henderson.
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Dr. Daniel Zelazny
University Orthopedics
19 Bradhurst Avenue, Ste. 1300N
Hawthorne,
NY
10532
Call (888) 834-8517
Hurt yourself during the holidays ice skating or playing basketball? If youve hurt your hand or sprained an ankle or injured yourself more seriously it is best you consult a sports medicine specialist who can advise you on the treatment you need. Board Certified Dr. Daniel Zelazny of Westchester, NY specializes in sports medicine and orthopedic trauma and is based in Westchester. Get yourself treated by him as soon as possible and get back to playing the sport you love in no time at all.
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Dr. Howard Luks
University Orthopaedics
19 Bradhurst Ave. Ste 1300N
Hawthorne,
NY
10532
Call (888) 834-8517
Having a critical knee injury can be very difficult for a person who is prone to being quite active in their everyday life. It is also challenging for an athlete who isn't able to take on further challenges in his sport of passion. If you are either an active individual or an athlete suffering from this particular problem and are in dire need of surgery, turning to any knee surgeon just won't cut it. That is why you need to seek care from Dr. Howard J. Luks, MD at University Orthopaedics, PC in Westchester, New York. He is a qualified medical professional who makes fulfilling your specific needs his number one priority.
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Lawrence Hospital Center | Orthopedics & Sports Medicine
Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville,
NY
10708
Call (888) 729-2857
Experiencing constant hand pain means that almost everything you do is agonizing. From eating a meal to cleaning around the house, you grit your teeth and keep going, always hoping tomorrow it will be gone. But it won't without action. Hand surgery with the Lawrence Hospital Center Department of Orthopedics & Sports Medicine near New Rochelle, New York can put a stop to your pain and have you back to doing the things you love.
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Lawrence Hospital Center | Orthopedics & Sports Medicine
Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville,
NY
10708
Call (888) 729-2857
Does your child have a birth defect? Is this condition effecting other areas of the child life? Now is the time to take action and get your child the help he/she deserves. Defects can cause low self-esteem for a child, especially in the "appearances are everything" world we live in today. Appearance is only one reason for pediatric surgery. Many birth defects if untreated can lead to medical complications as the child gets older. At Lawrence Hospital Center for Orthopedics and Sports Medicine in Bronxville, Westchester County, New York, they offer pediatric surgery to remove the birth defect.
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Lawrence Hospital Center | Orthopedics & Sports Medicine
Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville,
NY
10708
Call (888) 729-2857
When osteoarthritis or another painful orthopedic condition is keeping you immobile and in pain, you want the best in orthopedic surgeons so that you can know you in the best hands. Lawrence Hospital Center near the Sleepy Hollow, Mount Pleasant area makes the high tech service of a big city hospital available to patients in a community setting. And with more than 12,000 collective orthopaedic procedures preformed by Lawrence's surgeons, you can be certain that there is an wealth of experience behind you.
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Dr. Roger Pollock
Dr. Roger Pollock, M.D.
suite 202 One West Ridgewood Avenue
Paramus,
New jersey
07652
Call (888) 631-1911
Bergen County residents should look no further for a shoulder specialist than Roger G. Pollock, M.D. in Paramus, NJ, for all of their shoulder needs. Dr. Pollock's distinguished career as a shoulder specialist has given him the experience needed to help his patients find lasting relief under his surgical care and help choose treatments that are suitable for each case.
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Dr. Roger Pollock
Dr. Roger Pollock, M.D.
suite 202 One West Ridgewood Avenue
Paramus,
New jersey
07652
Call (888) 631-1911
Thanks to recent advancements in medical technology, shoulder surgery does not need to be as invasive as traditional open surgeries. Modern arthroscopy drastically reduces the amount of time needed to heal after surgery, and Roger G. Pollock, MD of Paramus, New Jersey is a respected arthroscopic shoulder surgeon serving New York and New Jersey.
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Lawrence Hospital Center | Orthopedics & Sports Medicine
Lawrence Hospital Center | Orthopedics & Sports Medicine
55 Palmer Avenue, First Floor
Bronxville,
NY
10708
Call (888) 729-2857
The team at Lawrence Hospital Center Orthopedics & Sports Medicine near White Plains, NY performs hip replacement, knee surgery, arthroscopic procedures, ankle surgery, and shoulder surgery.
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