For patients with a glucose disposition index (GDI) 30% of normal, remission was less likely. GDI can tell the doctor how well the pancreas is producing insulin, as well as how effectively the insulin is being used by the body to regulate the breakdown of fats and carbohydrates.
Remission in this scenario was defined as the patient no longer needing medication to achieve proper control of elevated blood sugar.
Lead author and bariatric surgeron, Richard A. Perugini, MD, claims, "The study shows beta cell function, the cells in the pancreas that produce insulin, and insulin dependence, not initial weight or subsequent weight loss, are the greatest predictors of potential diabetes remission after gastric bypass. The study further confirms Type 2 diabetes becomes more difficult to manage as it progresses."
The study involved 139 obese patients, with a body mass index between the ranges of 33 to 75 who were scheduled to have bariatric surgery. Each patient required medication to manage their type 2 diabetes before their operation.
The study results revealed that 36% of all bariatric surgery patients no longer required diabetic medications within two weeks of their operation. Additionally, 57% of patients required no diabetes medications within six months of their operation and 67% needed no further diabetes medications within 12 months of the procedure. Over 96% of patients on non-insulin diabetes medication with a GDI above 30% of normal achieved remission as well.
Other mechanisms aside from weight loss help gastric bypass patients control diabetes. Study participants lost on average 15 BMI points and a total of 59% of their weight after 12 months. The procedure brings about physiological changes in people, including how stomach hormones that regulate the metabolism of fats and sugars behave. According to some studies, type 2 diabetes symptoms improve greatly after weight loss surgery, even before substantial weight loss occurs.
There are over 20 million diabetics living in the USA today; that’s nearly three times as many as three decades ago, according to the Centers for Disease Control and Prevention. Over half of all type 2 diabetics in the USA have a BMI of at least thirty- 80% of those whose BMI is greater than 35 have at least one metabolic disease. Type 2 diabetes is responsible for the causing the seventh largest amount of deaths in America.